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- Title
Evaluating for Human Herpesvirus 6 in the Liver Explants of Children With Liver Failure of Unknown Etiology.
- Authors
Yang, Christine H; Sahoo, Malaya K; Fitzpatrick, Megan; Lau, Audrey H; Pinsky, Benjamin A; Martinez, Olivia M
- Abstract
<bold>Background: </bold>Liver failure of unknown etiology (LFUE) has a transplant-free survival rate <25%. Human herpesvirus 6 (HHV-6) may be associated with LFUE, but studies are limited by small sample size.<bold>Methods: </bold>We identified all children who underwent liver transplant for LFUE at a single quaternary children's hospital; 51/65 cases could be age matched with controls (children who underwent liver transplant for metabolic liver disease). Quantitative polymerase chain reaction for HHV-6 was performed on DNA from formalin-fixed paraffin-embedded liver explant tissue.<bold>Results: </bold>HHV-6 was detected in 34/51 cases (66.7%) and 19/51 controls (37.3%) (P = .005). Average HHV-6 viral load was 213207 copies/106 cells in positive cases (range: 7293-1102030) and 38115 copies/106 cells in positive controls (range: 1382-122375) (P = .0008). HHV-6 was present significantly more often in cases compared to controls in patients younger than 6 years. In particular, in patients younger than 3 years, HHV-6 was present in 13/27 cases (48.1%) and 2/27 controls (7.4%) (P = .0009).<bold>Conclusions: </bold>HHV-6 was detected in liver explants significantly more often and in higher quantities in children transplanted for LFUE compared to controls, suggesting HHV-6 should be evaluated in young children who present with LFUE.
- Subjects
LIVER failure; ETIOLOGY of diseases; LIVER transplantation; CHILDREN'S hospitals; LIVER; COMPARATIVE studies; HERPESVIRUS diseases; HERPESVIRUSES; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TRANSPLANTATION of organs, tissues, etc.; EVALUATION research; DISEASE complications
- Publication
Journal of Infectious Diseases, 2019, Vol 220, Issue 3, p361
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy644