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- Title
CD8+ T-Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes.
- Authors
Freeman, Michael L; Panigrahi, Soumya; Chen, Bonnie; Juchnowski, Steven; Sieg, Scott F; Lederman, Michael M; Funderburg, Nicholas T; Zidar, David A
- Abstract
Circulating CD8+ T cells and monocytes are activated during human immunodeficiency virus (HIV) infection and colocalize in the aortas of simian immunodeficiency virus-infected nonhuman primates. We hypothesized that CD8+ T cells could exert a proatherosclerotic effect via paracrine actions on monocytes. We found that T-cell receptor-stimulated CD8+ T cells induce monocytes to express tissue factor, a potent activator of coagulation. Tumor necrosis factor was both necessary and sufficient for this effect.
- Subjects
BLOOD coagulation; CELL culture; CELL receptors; COMPARATIVE studies; EPITHELIAL cells; HIV infections; RESEARCH methodology; MEDICAL cooperation; MONOCYTES; RESEARCH; T cells; THROMBOPLASTIN; TUMOR necrosis factors; EVALUATION research
- Publication
Journal of Infectious Diseases, 2019, Vol 220, Issue 1, p73
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz051