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- Title
A Cross-sectional Study of the Association Between Chronic Hepatitis C Virus Infection and Subclinical Coronary Atherosclerosis Among Participants in the Multicenter AIDS Cohort Study.
- Authors
McKibben, Rebeccah A.; Haberlen, Sabina A.; Post, Wendy S.; Brown, Todd T.; Budoff, Matthew; Witt, Mallory D.; Kingsley, Lawrence A.; Palella Jr., Frank J.; Thio, Chloe L.; Seaberg, Eric C.; Palella, Frank J Jr
- Abstract
<bold>Background: </bold>Hepatitis C virus (HCV) infection may increase the risk of cardiovascular disease (CVD). We evaluated the association of chronic HCV infection and coronary atherosclerosis among participants in the Multicenter AIDS Cohort Study.<bold>Methods: </bold>We assessed 994 men with or without human immunodeficiency virus (HIV) infection (87 of whom had chronic HCV infection) for coronary plaque, using noncontrast coronary computed tomography (CT); 755 also underwent CT angiography. We then evaluated the associations of chronic HCV infection and HIV infection with measures of plaque prevalence, extent, and stenosis.<bold>Results: </bold>After adjustment for demographic characteristics, HIV serostatus, behaviors, and CVD risk factors, chronic HCV infection was significantly associated with a higher prevalence of coronary artery calcium (prevalence ratio, 1.29; 95% confidence interval [CI], 1.02-1.63), any plaque (prevalence ratio, 1.26; 95% CI, 1.09-1.45), and noncalcified plaque (prevalence ratio, 1.42; 95% CI, 1.16-1.75). Chronic HCV infection and HIV infection were independently associated with the prevalence of any plaque and of noncalcified plaque, but there was no evidence of a synergistic effect due to HIV/HCV coinfection. The prevalences of coronary artery calcium, any plaque, noncalcified plaque, a mixture of noncalcified and calcified plaque, and calcified plaque were significantly higher among men with an HCV RNA load of ≥2 × 10(6) IU/mL, compared with findings among men without chronic HCV infection.<bold>Conclusions: </bold>Chronic HCV infection is associated with subclinical CVD, suggesting that vigilant assessments of cardiovascular risk are warranted for HCV-infected individuals. Future research should determine whether HCV infection duration or HCV treatment influence coronary plaque development.
- Subjects
HEPATITIS C; ATHEROSCLEROSIS; AIDS research; CARDIOVASCULAR diseases risk factors; DISEASE prevalence
- Publication
Journal of Infectious Diseases, 2016, Vol 213, Issue 2, p257
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv396