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- Title
Effectiveness of Influenza Vaccine Against Life-threatening RT-PCR-confirmed Influenza Illness in US Children, 2010–2012.
- Authors
Ferdinands, Jill M.; Olsho, Lauren E. W.; Agan, Anna A.; Bhat, Niranjan; Sullivan, Ryan M.; Hall, Mark; Mourani, Peter M.; Thompson, Mark; Randolph, Adrienne G.
- Abstract
Background. No studies have examined the effectiveness of influenza vaccine against intensive care unit (ICU) admission associated with influenza virus infection among children.Methods. In 2010–2011 and 2011–2012, children aged 6 months to 17 years admitted to 21 US pediatric intensive care units (PICUs) with acute severe respiratory illness and testing positive for influenza were enrolled as cases; children who tested negative were PICU controls. Community controls were children without an influenza-related hospitalization, matched to cases by comorbidities and geographic region. Vaccine effectiveness was estimated with logistic regression models.Results. We analyzed data from 44 cases, 172 PICU controls, and 93 community controls. Eighteen percent of cases, 31% of PICU controls, and 51% of community controls were fully vaccinated. Compared to unvaccinated children, children who were fully vaccinated were 74% (95% CI, 19% to 91%) or 82% (95% CI, 23% to 96%) less likely to be admitted to a PICU for influenza compared to PICU controls or community controls, respectively. Receipt of 1 dose of vaccine among children for whom 2 doses were recommended was not protective.Conclusions. During the 2010–2011 and 2011–2012 US influenza seasons, influenza vaccination was associated with a three-quarters reduction in the risk of life-threatening influenza illness in children.
- Subjects
UNITED States; INFLUENZA treatment; INFLUENZA vaccines; FLU vaccine efficacy; PEDIATRIC intensive care; REVERSE transcriptase polymerase chain reaction; INFLUENZA statistics; VACCINATION; THERAPEUTICS
- Publication
Journal of Infectious Diseases, 2014, Vol 210, Issue 5, p674
- ISSN
0022-1899
- Publication type
Case Study
- DOI
10.1093/infdis/jiu185