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- Title
Toll-like Receptor Polymorphism Associations With HIV-1 Outcomes Among Sub-Saharan Africans.
- Authors
Mackelprang, Romel D.; Bigham, Abigail W.; Celum, Connie; de Bruyn, Guy; Beima-Sofie, Kristin; John-Stewart, Grace; Ronald, Allan; Mugo, Nelly R.; Buckingham, Kati J.; Bamshad, Michael J.; Mullins, James I.; McElrath, M. Juliana; Lingappa, Jairam R.
- Abstract
Objective. We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples.Methods. Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls.Results. TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression.Conclusions. TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships.
- Subjects
TOLL-like receptors; SINGLE nucleotide polymorphisms; DISEASE progression; HAPLOTYPES; HIV-1 glycoprotein 120
- Publication
Journal of Infectious Diseases, 2014, Vol 209, Issue 10, p1623
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jit807