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- Title
A neuronal transmembrane protein LRFN4 induces monocyte/macrophage migration via actin cytoskeleton reorganization
- Authors
Konakahara, Shu; Saitou, Maki; Hori, Shunsuke; Nakane, Taku; Murai, Kenko; Itoh, Reiko; Shinsaka, Aya; Kohroki, Junya; Kawakami, Takao; Kajikawa, Masunori; Masuho, Yasuhiko
- Abstract
Abstract: Leucine-rich repeat and fibronectin type III domain-containing (LRFN) family proteins are thought to be neuronal-specific proteins that play essential roles in neurite outgrowth and synapse formation. Here, we focused on expression and function of LRFN4, the fourth member of the LRFN family, in non-neural tissues. We found that LRFN4 was expressed in a wide variety of cancer and leukemia cell lines. We also found that expression of LRFN4 in the monocytic cell line THP-1 and in primary monocytes was upregulated following macrophage differentiation. Furthermore, we demonstrated that LRFN4 signaling regulated both the transendothelial migration of THP-1 cells and the elongation of THP-1 cells via actin cytoskeleton reorganization. Our data indicate that LRFN4 signaling plays an important role in the migration of monocytes/macrophages.
- Subjects
NEURONS; MEMBRANE proteins; MONOCYTES; MACROPHAGES; CELL migration; ACTIN; FIBRONECTINS; LEUCINE; MONOCLONAL antibodies
- Publication
FEBS Letters, 2011, Vol 585, Issue 14, p2377
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.06.011