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- Title
Adaptation of Saccharomyces cerevisiae to high hydrostatic pressure causing growth inhibition
- Authors
Iwahashi, Hitoshi; Odani, Mine; Ishidou, Emi; Kitagawa, Emiko
- Abstract
Abstract: Genome-wide mRNA expression profiles of Saccharomyces cerevisiae growing under hydrostatic pressure were characterized. We selected a hydrostatic pressure of 30MPa at 25°C because yeast cells were able to grow under these conditions, while cell size and complexity were increased after decompression. Functional characterization of pressure-induced genes suggests that genes involved in protein metabolism and membrane metabolism were induced. The response to 30MPa was significantly different from that observed under lethal conditions because protein degradation was not activated under 30MPa pressure. Strongly induced genes those that contribute to membrane metabolism and which are also induced by detergents, oils, and membrane stabilizers.
- Subjects
SACCHAROMYCES cerevisiae; LEAVENING agents; NUCLEIC acids; MESSENGER RNA
- Publication
FEBS Letters, 2005, Vol 579, Issue 13, p2847
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.03.100