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- Title
Phytochemical analysis and in-vitro anti-African swine fever virus activity of extracts and fractions of Ancistrocladus uncinatus, Hutch and Dalziel (Ancistrocladaceae).
- Authors
Fasina, Folorunso O.; Olaokun, Oyinlola O.; Oladipo, Olusola O.; Fasina, Margaret M.; Makinde, Adesoji A.; Heath, Livio; Bastos, Armanda D. S.
- Abstract
Background: African swine fever (ASF), a highly contagious fatal acute haemorrhagic viral disease of pigs currently has no treatment or vaccination protocol and it threatens the pig industry worldwide. Recent outbreaks were managed by farmers with ethnoveterinary preparations with various claims of effectiveness. Results: We identified 35 compounds using GC-MS protocol and ASF virus (NIG 99) was significantly reduced by some extracts and fractions of the plant. However, the plant was poorly extracted by water and cytotoxicity was found to be a major problem with the use of the plant since its extracts also reduced the primary cells used in the assay. Conclusion: It is confirmed that the plant has antiviral potentials against ASF virus and farmers' claims seem to have certain degree of veracity, but finding the best means of exploring the potential of the plant while reducing its cytotoxic effect in-vitro and in-vivo will be necessary.
- Subjects
CLASSICAL swine fever; AFRICAN swine fever virus; IRIDOVIRUSES; PREVENTION of communicable diseases; ARBOVIRUS diseases in animals
- Publication
BMC Veterinary Research, 2013, Vol 9, Issue 1, p1
- ISSN
1746-6148
- Publication type
Article
- DOI
10.1186/1746-6148-9-120