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- Title
The Impact of Bariatric Surgery on Hepatic Function and Predictors of Liver Steatosis and Fibrosis.
- Authors
Borges-Canha, Marta; Neves, João Sérgio; Mendonça, Fernando; Silva, Maria Manuel; Costa, Cláudia; Cabral, Pedro M.; Guerreiro, Vanessa; Lourenço, Rita; Meira, Patrícia; Salazar, Daniela; Ferreira, Maria João; Pedro, Jorge; Leite, Ana; Viana, Sara; Sande, Ana; Belo, Sandra; Lau, Eva; Freitas, Paula; Carvalho, Davide
- Abstract
Purpose: To evaluate the variation in parameters of hepatic function and in the scores Fatty Liver Index (FLI; predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis), 1 year after bariatric surgery. Material and Methods: This is a observational retrospective cohort study in patients with morbid obesity that underwent bariatric surgery in our centre. We used two linear regression models: (1) unadjusted and (2) adjusted for surgery type, sex, age, body mass index, diabetes, and dyslipidaemia. Results: The included population (n = 1955) had an average age of 43.1 ± 10 years and 85.8% were female. Diabetes was present in 32.4% of the patients, 45.1% had dyslipidaemia, and 62.2% had hypertension. Twelve percent were submitted to gastric band, 29.6% to sleeve gastrectomy, and 58.4% to gastric bypass. We observed a relevant decrease in transaminases and gamma-glutamyltransferase, and an increase in alkaline phosphatase and total bilirubin. Both FLI and BARD markedly decrease 1 year after surgery (p < 0.01). Comparing the surgical procedures, sleeve gastrectomy was associated with a greater reduction of hepatic enzymes and of both FLI and BARD compared with gastric band. Comparing with gastric bypass, sleeve was associated with a greater reduction of transaminases and alkaline phosphatase, but a smaller reduction of FLI and BARD. Conclusion: Bariatric surgery is associated with a reduction of the hepatic enzymes and an improvement of FLI and BARD. It may represent an effective therapeutic approach for NAFLD.
- Subjects
BARIATRIC surgery; GASTRIC banding; LIVER surgery; OPERATIVE surgery; GASTRIC bypass; FATTY degeneration; ALKALINE phosphatase
- Publication
Obesity Surgery, 2020, Vol 30, Issue 8, p2935
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-020-04622-0