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- Title
A Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Acetaminophen on Hospital Length of Stay in Obese Individuals Undergoing Sleeve Gastrectomy.
- Authors
Cooke, Farrell E.; Samuels, Jon D.; Gadalla, Farida; Goldstein, Peter A.; Pomp, Alfons; Afaneh, Cheguevara; Dakin, Gregory F.; Wu, Xian
- Abstract
Background: Retrospective studies indicate that acetaminophen iv administration reduces hospital length of stay (LoS) and opiate consumption in patients undergoing bariatric surgery.Objective: This study sought to determine whether using acetaminophen iv in morbidly obese subjects undergoing sleeve gastrectomy decreased LoS and total hospital charges as compared to patients receiving saline placebo.Setting: Single-center university hospitalMethods: Using a randomized, double-blind, placebo-controlled design, subjects were assigned to receive either acetaminophen iv (group A) or saline placebo iv (group P). Data were collected between Jan 1 and Dec 31, 2016. Group A received acetaminophen every 6 h for a total of four doses. The first dose was administered following the induction of general anesthesia; group P received saline iv on the same schedule. Anesthetic management and prophylactic antiemetic regimen were standardized in all subjects. Postoperative pain management consisted of hydromorphone via patient-controlled infusion pump. Primary outcomes include hospital LoS and associated hospital costs. Secondary outcomes include patient satisfaction and postoperative nausea and pain scores.Results: Subject demographics (n = 127) and intraoperative management were similar in the two groups. Across all subjects, median hospital LoS in group A (n = 63) was 1.87 vs. 1.97 days in group P (n = 64) (p = 0.03, Wilcoxon rank-sum test). Postoperatively, daily quality-of-recovery (QoR-15) scores, narcotic consumption, and the use of rescue antiemetics were not significantly different between groups. Median hospital costs were as follows: group A, $12,885 vs. group P, $12,977 (n = 64).Conclusions: Acetaminophen iv may reduce hospital LoS in subjects undergoing sleeve gastrectomy.
- Subjects
RANDOMIZED controlled trials; ACETAMINOPHEN; MORBID obesity; BARIATRIC surgery; BODY mass index
- Publication
Obesity Surgery, 2018, Vol 28, Issue 10, p2998
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-018-3316-7