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- Title
OXIDATIVE STRESS OF CHRONIC KIDNEY DISEASE.
- Authors
Mircescu, G.
- Abstract
Oxidative stress is defined as a rupture in the prooxidant-antioxidant balance in favor of the former, leading to characteristic changes in biomolecules of all types, and to tissue damage. It was implied in ageing-related processes, both by direct actions of various oxidative adducts and by its cardiovascular consequences. In the latest years, it has become evident that chronic kidney disease (CKD) is itself a condition characterized by oxidative stress. Although conflictual results were reported in non-dialysis CKD patients, there is an increasing trend in oxidative stress markers and a decreasing one in antioxidative activity along with progressive reduction in glomerular filtration rate. A combination of inflammation, abnormal nutrition, disturbed metabolism by the uremic milieu and defective renal clearance seems to be the cause. Clearly, longitudinal studies with larger participation are necessary to define the precise contribution of each element and the relationships between oxidative stress and CKD progression. In dialysis CKD patients, bioincompatibility reactions during HD sessions (dialyzor membrane, dialysis solution), anemia and its therapy (iv iron) come into play. The clinical consequences of oxidative stress are difficult to ascertain, because oxidative stress, inflammation and malnutrition were found to be, in various proportion, strong predictors of outcome in CKD patients, but the precise contribution of each factor is difficult to elucidate for the moment.
- Subjects
OXIDATIVE stress; OXIDATION-reduction reaction; NUTRITION disorders; KIDNEY diseases; HEMODIALYSIS patients; LONGITUDINAL method; MALNUTRITION
- Publication
Acta Endocrinologica (1841-0987), 2008, Vol 4, Issue 4, p433
- ISSN
1841-0987
- Publication type
Article
- DOI
10.4183/aeb.2008.433