We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Additive effect of the mutations in the ß3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome.
- Authors
Kim, O Y; Cho, H. W; Park, H Y; Jang, Y; Lee, J H
- Abstract
OBJECTIVE:: To analyze the effects of the mutations in the ß3-adrenoceptor (ß3-AR) gene and/or uncoupling protein3 (UCP3) gene promoter on body fat distribution and glycemic control after mild weight reduction in overweight-obese subjects with coronary artery disease (CAD) or metabolic syndrome. DESIGN:: Clinical intervention study of the -300?kcal/day mild weight reduction program for 12 weeks. SUBJECTS:: A total of 224 overweight-obese subjects with CAD or metabolic disorder, subdivided into the following four categories: (1) wild type (TT-CC, n=73); (2) only UCP3 promoter variant (TT-CT/TT, n=90); (3) only ß3-AR variant (TA/AA-CC, n=29); (4) both variants (TA/AA-CT/TT, n=32). MEASUREMENT:: Body mass index (BMI), blood pressure, calorie intakes, body fat distribution, serum glucose, insulin, free fatty acids, C-peptide and lipids before and after weight reduction. RESULTS:: After 12 weeks, all subjects lost approximately 5% of their initial body weight. Despite similar weight reduction, the highest decreases in abdominal adipose tissue at both L1 and L4 levels were observed in the ‘wild-type’ group (P<0.001) and the second highest in ‘only UPC3 promoter variant’ group (P<0.001). On the other hand, both variant-carriers had the smallest reduction only in visceral fat area at the L4 level. All subjects except both variant-carriers showed significant reductions in the fasting levels of glucose and FFA. The response areas of glucose (P<0.01) and insulin (P<0.05) were reduced largest in the ‘wild-type’ group and second largest in the ‘UCP3 promoter variant’ group. CONCLUSION:: All the four groups showed similar weight reduction after -300?kcal/d for 12 weeks. However, the beneficial effects on body fat distribution and glycemic control were greatest in the ‘wild-type’ group and smallest in ‘both variants’ group. In addition, these effects were less beneficial in carriers with ß3-AR gene variant than with UCP3 gene promoter variant.International Journal of Obesity (2004) 28, 434-441. doi:10.1038/sj.ijo.0802562
- Subjects
GENETIC mutation; CORONARY disease; OBESITY; ADRENERGIC receptors; WEIGHT loss; ADIPOSE tissues; FATTY acids
- Publication
International Journal of Obesity & Related Metabolic Disorders, 2004, Vol 28, Issue 3, p434
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0802562