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- Title
Pathology and ploidy in the prognosis of gastric cancer with no extranodal metastasis.
- Authors
Rugge, Massimo; Sonego, Fulvia; Panozzo, Marina; Baffa, Raffale; Rubio, Juan; Farinati, Fabio; Nitti, Donato; Ninfo, Vito; Ming, Si-Chun; Rugge, M; Sonego, F; Panozzo, M; Baffa, R; Rubio, J Jr; Farinati, F; Nitti, D; Ninfo, V; Ming, S C
- Abstract
<bold>Background: </bold>The prognostic relevance of morphology in advanced gastric cancer is well known. Data on tumor cell DNA content are still inadequate and contradictory.<bold>Methods: </bold>Morphologic parameters and DNA ploidy were evaluated in 76 gastric cancer patients with no extranodal metastases (Stage I, 10 cases; Stage II, 20 cases; and Stage III, 46 cases), using formalin-fixed paraffin-embedded tissue. All cases were followed for at least 6 years after surgery or until death.<bold>Results: </bold>Among the potential prognostic factors analyzed by Mantel-Cox and generalized Wilcoxon statistics, male sex (P = 0.02), cardiac location of neoplasia (P = 0.02), deeper infiltration of the gastric wall (P = 0.001), vascular neoplastic invasion (P = 0.006), metastatic lymph nodes (P = 0.001), pathologic stage (P = 0.0001), and aneuploidy (P = 0.01) were significantly associated with lower survival rate. Testing of all of the above-mentioned variables by the Cox stepwise multiple regression model disclosed that factors independently associated with survival were stage (P = 0.0001), ploidy (P = 0.0006), and vascular carcinomatous invasion (P = 0.01).<bold>Conclusions: </bold>In gastric cancer with no extranodal metastases, DNA ploidy was found to be the most significant prognostic parameter after pathologic stage.
- Publication
Cancer (0008543X), 1994, Vol 73, Issue 4, p1127
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19940215)73:4<1127::AID-CNCR2820730402>3.0.CO;2-Q