We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An immunohistologic evaluation of C-erbB-2 gene product in patients with urinary bladder carcinoma.
- Authors
Sato, Kazunari; Moriyama, Masatsugu; Mori, Shigeo; Saito, Masahiro; Watanuki, Tsutomu; Terada, Kunihiko; Okuhara, Eiji; Akiyama, Tetsu; Toyoshima, Kumao; Yamamoto, Tadashi; Kato, Tetsuro; Sato, K; Moriyama, M; Mori, S; Saito, M; Watanuki, T; Terada, K; Okuhara, E; Akiyama, T; Toyoshima, K
- Abstract
<bold>Background: </bold>Amplification or overexpression of the c-erbB-2 gene have been reported to correlate with poor patient prognosis in human breast, gastric, and ovarian cancer. Recently, the c-erbB-2 gene product was found to be expressed frequently in the urinary bladder carcinoma. In the current study, the presence of the c-erbB-2 gene product in urinary bladder carcinomas was compared with patient outcome to evaluate whether c-erbB-2 gene product could identify a subset of patients who are destined to have a poor prognosis.<bold>Methods: </bold>Immunohistologic study of the c-erbB-2 gene product was done in formaldehyde-fixed paraffin-embedded tissue specimens obtained from 88 transitional cell carcinomas of the human urinary bladder. Eighty-three patients who underwent complete tumor resection by total cystoprostatectomy (30 patients) or by bladder-preserving operations such as transurethral surgery (50 patients) or partial cystectomy (3 patients) entered a follow-up study. The other five patients did not enter the follow-up study because of lost follow-up (2 patients) or distant metastasis at the time of surgery.<bold>Results: </bold>The c-erbB-2 gene product was expressed in 23 of 88 patients (26%), showing an increase in the expression rate corresponding to the advancement of tumor grade (P < 0.05) and tumor stage (P < 0.2). The 5-year disease-free survival rate was 48.5% for patients with c-erbB-2 negative tumors versus 9.7% for those with c-erbB-2 positive tumors (P < 0.01). The 5-year actuarial survival rate was 65.5% for patients with c-erbB-2 negative tumors versus 41.8% for those with c-erbB-2 positive tumors (P < 0.05). Multivariate analysis using Cox regression model showed that the c-erbB-2 gene product tissue status was a significant prognostic factor independent of grade and stage of the tumor.<bold>Conclusions: </bold>The results suggest that the c-erbB-2 gene product could be a tumor marker to identify a malignant subgroup in bladder carcinomas.
- Publication
Cancer (0008543X), 1992, Vol 70, Issue 10, p2493
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19921115)70:10<2493::AID-CNCR2820701017>3.0.CO;2-K