We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antibody Persistence 3 Years after Immunization of Adolescents with Quadrivalent Meningococcal Conjugate Vaccine.
- Authors
Vu, David M.; Welsch, Jo Anne; Zuno-Mitchell, Patricia; Cruz, Josefa V. Dela; Granoff, Dan M.
- Abstract
Background. A quadrivalent meningococcal conjugate vaccine (MCV-4) is recommended for United States teenagers. The duration of protective immunity is unknown. We investigated serum antibody persistence 3 years after vaccination of adolescents. Methods. Serum samples from participants of a randomized trial who had received MCV-4 (n = 52) or polysaccharide vaccine (MPSV-4; n = 48) and from unvaccinated controls (n = 60) were assayed for serogroups C, W-135, and Y anticapsular antibody concentrations by use of a radioantigen binding assay and for bactericidal activity (in a human complement assay) and passive protection against serogroup C bacteremia in an infant rat model. Results. A higher proportion of participants in the vaccine groups had protective bactericidal titers (⩾ 1:4), compared with that in the control group (for MCV-4 recipients vs. controls, P < .01; for MPSV-4 recipients vs. controls, P ⩽ .06). More MCV-4 recipients had W-135 bactericidal titers ⩾1:4 than did MPSV-4 recipients (P = .01). More MCV-4 recipients had passive protective activity against serogroup C bacteremia than did MPSV- 4 recipients (76% vs. 49%; P < .01). The differences in protective activity were largest between participants in the vaccine groups with bactericidal titers <1:4 (63% protective in MCV-4 recipients vs. 31% protective in MPSV-4 recipients; P = .01). Conclusions. Compared with MPSV-4, MCV-4 elicited greater persistence of antibody activity against serogroups C and W-135 at 3 years after vaccination in adolescents. On the basis of passive protection data in an infant rat model, bactericidal titers ⩾ 1:4 underestimate protective immunity.
- Subjects
NEISSERIA meningitidis; IMMUNOGLOBULINS; VACCINATION; IMMUNITY; BLOOD plasma; IMMUNIZATION
- Publication
Journal of Infectious Diseases, 2006, Vol 193, Issue 6, p821
- ISSN
0022-1899
- Publication type
Article