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- Title
Drug-selected resistance mutations and non-B subtypes in antiretroviral-naive adults with established human immunodeficiency virus infection.
- Authors
Hanna, George J.; Balaguera, Henri U.; Freedberg, Kenneth A.; Werner, Barbara G.; Craven, Kathleen A. Steger; Craven, Donald E.; D'Aquila, Richard T.; Steger Craven, Kathleen A
- Abstract
The prevalence of human immunodeficiency virus (HIV) type 1 antiretroviral resistance is expected to be higher in recently infected antiretroviral-naive individuals than in those who have been infected longer. Antiretroviral-naive HIV-1-infected adults who presented to an outpatient clinic in an urban hospital in Boston for initial evaluation in 1999 were screened for drug-selected resistance mutations and phylogenetic subtype. Drug-selected mutations were identified in 16 (18%) of 88 subjects. Twelve (14%) included mutations associated with nucleoside reverse-transcriptase inhibitors, 4 (5%) included mutations associated with nonnucleoside reverse-transcriptase inhibitors, and 3 (3%) included mutations associated with protease inhibitors. Two (2%) had resistance mutations associated with multiple classes of drugs. Nine (10%) subjects had infection with non-B subtype HIV-1 and did not have drug-selected mutations. Serological results indicated infection for >/=6 months. Drug-selected mutations or non-B subtypes were detected in a substantial portion of antiretroviral-naive adults who had been infected for at least 6 months.
- Subjects
DRUG resistance; HIV-positive persons; GENETIC mutation
- Publication
Journal of Infectious Diseases, 2003, Vol 188, Issue 7, p986
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/378280