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- Title
Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites.
- Authors
Hoffman, Stephen L.; Goh, Lucy M.L.; Luke, Thomas C.; Schneider, Imogene; Le, Thong P.; Doolan, Denise L.; Sacci, John; de la Vega, Patricia; Dowler, Megan; Paul, Chris; Gordon, Daniel M.; Stoute, Jose A.; Church, L.W. Preston; Sedegah, Martha; Heppner, D. Gray; Ballou, W.Ripley; Richie, Thomas L.
- Abstract
During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. Ten volunteers were first challenged by the bites of Pf-infected mosquitoes 2-9 weeks after the last immunization, and all were protected. A volunteer challenged 10 weeks after the last immunization was not protected. Five previously protected volunteers were rechallenged 23-42 weeks after a secondary immunization, and 4 were protected. Two volunteers were protected when rechallenged with a heterologous Pf strain (7G8). In total, there was protection in 24 of 26 challenges. These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks.
- Subjects
UNITED States; MALARIA; PLASMODIUM falciparum; VACCINATION
- Publication
Journal of Infectious Diseases, 2002, Vol 185, Issue 8, p1155
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/339409