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- Title
Protective role of Ipomoea aquatica Forsk. crude extract on rat tissues in the presence of acephate and carbofuran by histopathology and cytometric determination.
- Authors
Datta, Sanjukta; Manna, Krishnendu; Dey, Sanjit; Dhar, Pubali; Ghosh, Mahua
- Abstract
Ipomoea aquatica Forsk., commonly called water spinach ('kalmi' in Bengali) is an underexploited local green leafy vegetable having enormous scope as a cheap antioxidant source. The study explores the ameliorative effect of aqueous I. aquatica extract (IAE) in acephate and carbofuran treated Wistar male rats. Aqueous IAE (@ 20 mg/kg body wt.), administered to rats treated with organophosphate acephate (@ 30 mg/kg body wt.) and carbamate carbofuran (@ 0.1 mg/kg body wt.), attenuated the cholinesterase activity in brain, liver and cellular blood and reformed the histological perturbations in the brain cortex as well as the kidney anomalies, to a good extent. The IAE also upregulated the NF-E2-related factor-2 (Nrf-2) and MnSOD gene expression against pesticide toxicity. Hence, results of the present study intervenes into a new approach of justifying the deleterious side effects of pesticides that are commonly used, and how green leafy vegetables can help ameliorate those harmful effects.
- Subjects
IPOMOEA aquatica; ACEPHATE; CARBOFURAN; TISSUE physiology; HISTOPATHOLOGY
- Publication
Indian Journal of Experimental Biology, 2021, Vol 59, Issue 2, p118
- ISSN
0019-5189
- Publication type
Article