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- Title
Augmented photoswitching modulates immune signaling.
- Authors
Yixin Zhang; Erdmann, Frank; Fischer, Gunter
- Abstract
Reversible and non-invasive photoswitching of the immunosuppressive effect of a drug would be a very valuable tool for precisely regulating the immune system. Using a combination of protein borrowing and two-photon photoisomerization, we designed and synthesized derivatives of cyclosporin A. Here we demonstrate photoswitching of the local conformation within small molecules, which we used to modulate inhibitory potencies for cyclophilin, influence ternary and quaternary complex formations and regulate T-cell transcriptional activation in situ.
- Subjects
IMMUNOREGULATION; CONFORMATIONAL analysis; IMMUNE system; T-cell receptor genes; TRANSCRIPTION factors; SUPPRESSOR cells
- Publication
Nature Chemical Biology, 2009, Vol 5, Issue 10, p724
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.214