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- Title
Significance of altered glycosyltransferase expression levels in oral cancer.
- Authors
Goni, Mallikarjun; Desai, Anil Kumar; Kumar, Niranjan; Hegde, Veda; Javaregowda, Palaksha Kanive; Virupakshaiah, D. B. M.
- Abstract
We evaluate the relative quantification of mRNA expression levels of the gene encoding an enzyme that catalyses initial step in glycosylation of dolichol-linked oligosaccharide such as dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 (DPAGT1). Furthermore, beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) and alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase (MGAT5) mediated N-glycosylation, selected a2, 3, a2, 6 sialyltransferases families and sialidase by using the Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Thirty human oral cancer tissue samples and twelve control samples were examined. Results indicated significant upregulation of ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1) in oral cancer compared to controls. Additionally, the expressions of DPAGT1, MGAT3, MGAT5, ST3 betagalactoside alpha-2,3-sialyltransferase 1 (ST3GAL1), ST6 beta-galactoside alpha-2,6-sialyltransferase 1 (ST6- GAL1), and ST6GALNAC1 were considerably higher in the tumour in tongue lesion compared to the buccal cavity. Hence, our experiment demonstrates significance of glycosyltransferases in the progression of oral cancer.
- Subjects
ORAL cancer; SIALYLTRANSFERASES; GENE expression; GLYCOSYLTRANSFERASES; CANCER invasiveness
- Publication
Current Science (00113891), 2022, Vol 123, Issue 1, p52
- ISSN
0011-3891
- Publication type
Article
- DOI
10.18520/cs/v123/i1/52-58