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- Title
Marine Antitumor Drugs: Status, Shortfalls and Strategies.
- Authors
Bhatnagar, Ira; Se-Kwon Kim
- Abstract
Cancer is considered as one of the deadliest diseases in the medical field. Apart from the preventive therapies, it is important to find a curative measure which holds no loopholes and acts accurately and precisely to curb cancer. Over the past few decades, there have been advances in this field and there are many antitumor compounds available on the market, which are of natural as well as synthetic origin. Marine chemotherapy is well recognized nowadays and profound development has been achieved by researchers to deal with different molecular pathways of tumors. However, the marine environment has been less explored for the production of safe and novel antitumor compounds. The reason is a number of shortfalls in this field. Though ample reviews cover the importance and applications of various anticancerous compounds from marine natural products, in the present review, we have tried to bring the current status of antitumor research based on marine inhibitors of cancer signaling pathways. In addition, focus has been placed on the shortfalls and probable strategies in the arena of marine antitumor drug discovery.
- Subjects
MARINE pharmacology; ANTINEOPLASTIC agents; CANCER treatment; DRUG therapy; MARINE organisms
- Publication
Marine Drugs, 2010, Vol 8, Issue 10, p2702
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md8102702