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- Title
RNA targeting by small molecules: Binding of protoberberine, benzophenanthridine and aristolochia alkaloids to various RNA structures.
- Authors
Kumar, Gopinatha
- Abstract
Studies on RNA targeting by small molecules to specifically control certain cellular functions is an area of remarkable current interest. For this purpose, a basic understanding of the molecular aspects of the interaction of small molecules with various RNA structures is essential. Alkaloids are a group of natural products with potential therapeutic utility, and very recently, their interaction with many RNA structures have been reported. Especially noteworthy are the protoberberines and aristolochia alkaloids distributed widely in many botanical families. Many of the alkaloids of these group exhibit excellent binding affinity to many RNA structures that may be exploited to develop RNA targeted therapeutics. This review attempts to present the current status on the understanding of the interaction of these alkaloids with various RNA structures, mainly highlighting the biophysical aspects.
- Subjects
RNA; MOLECULAR biology; PROTOBERBERINE; BENZOPHENANTHRIDINE alkaloids; ARISTOLOCHIA; BIOPHYSICS
- Publication
Journal of Biosciences, 2012, Vol 37, Issue 3, p539
- ISSN
0250-5991
- Publication type
Article
- DOI
10.1007/s12038-012-9217-3