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- Title
Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer.
- Authors
Irurzun-Arana, Itziar; Janda, Alvaro; Ardanza-Trevijano, Sergio; Trocóniz, Iñaki F.
- Abstract
Numerous problems encountered in computational biology can be formulated as optimization problems. In this context, optimization of drug release characteristics or dosing schedules for anticancer agents has become a prominent area not only for the development of new drugs, but also for established drugs. However, in complex systems, optimization of drug exposure is not a trivial task and cannot be efficiently addressed through trial-error simulation exercises. Finding a solution to those problems is a challenging task which requires more advanced strategies like optimal control theory. In this work, we perform an optimal control analysis on a previously developed computational model for the testosterone effects of Triptorelin in prostate cancer patients with the goal of finding optimal drug-release characteristics. We demonstrate how numerical control optimization of non-linear models can be used to find better therapeutic approaches in order to improve the final outcome of the patients.
- Subjects
PROSTATE cancer treatment; ANTINEOPLASTIC agents; PHYSIOLOGICAL effects of testosterone; DRUG delivery systems; PROSTATE diseases
- Publication
PLoS Computational Biology, 2018, Vol 14, Issue 3, p1
- ISSN
1553-734X
- Publication type
Article
- DOI
10.1371/journal.pcbi.1006087