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- Title
Assessment of Lipoprotein (A) value in cerebrovascular accident cases of Tripura, Northeast India.
- Authors
Debnath, Tapan; Das, Arpita; Jamatia, Elvia; Chakraborty, Avik; Roy, Sankar
- Abstract
Background: Atherosclerotic cardiovascular disorders, such as stroke, have been linked to the formation of lipoprotein (A) [Lp(a)], a genetically determined lipoprotein variation. Elevated Lp(a) is a crucial component in the pathogenesis of stroke since it is linked to an increased risk of ischaemic stroke. The study assessed Lp(a) levels in acute stroke patients. Methods: 49 stroke individuals and 49 age- and sex-matched healthy participants participated in the study. Lipid profiles, serum Lp(a) levels, and several biochemical markers were assessed. SPSS software was utilised for statistical analyses, with a significance threshold of p < 0.05. Results: The mean age of stroke patients was 61 years, with 46.94% being female. Elevated Lp(a) levels were observed in stroke patients (57.01 ± 15.99 mg/dL) compared to controls (17.75 ± 11.61 mg/dL), with a significant difference (p < 0.0001). Elevated Lp(a) levels were found in 85.71% of cases and in only one control subject. Females had higher mean Lp(a) levels (61.76 ± 15.93 mg/dL) than males (52.26 ± 12.05 mg/dL) among stroke patients (p < 0.05). Conclusion: Raised Lp(a) levels are significantly correlated with acute stroke in this cohort, particularly among females. Dyslipidemia is also prevalent among stroke patients. These findings highlight the importance of Lp(a) as an independent risk factor for stroke. Recommendations: Routine screening for Lp(a) levels in individuals at risk of cardiovascular diseases, especially those with a family history or existing comorbidities, is recommended. Further research into targeted therapies to lower Lp(a) levels is essential.
- Subjects
ISCHEMIC stroke; DISEASE risk factors; STROKE patients; BIOMARKERS; MEDICAL screening
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 7, p1903
- ISSN
0975-3583
- Publication type
Article