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- Title
Rosa sterilis Juice Alleviated Breast Cancer by Triggering the Mitochondrial Apoptosis Pathway and Suppressing the Jak2/Stat3 Pathway.
- Authors
Wang, Wenxi; Huang, Shaolin; Li, Sha; Li, Xingjie; Ling, Yihan; Wang, Xiaomeng; Zhang, Shuwen; Zhou, Dingzi; Yin, Wenya
- Abstract
Rosa sterilis (RS) is a characteristic fruit in southwestern China that has numerous health benefits; however, its pharmacological effect needs further clarification, especially with respect to the exploration of its potential anti-breast-cancer effect, as there are still knowledge gaps in this regard. This study was designed to investigate the protective effects of Rosa sterilis juice (RSJ) on breast cancer (BC) through in vitro cellular experiments and by establishing mouse 4T1 breast xenograft tumors. This study also had the aim of elucidating RSJ's underlying mechanisms. RSJ can inhibit cell proliferation, affect cell morphology, and impact the clone formation ability of BC; furthermore, it can promote apoptosis by triggering the mitochondrial apoptosis pathway. In mouse 4T1 breast xenograft tumors, RSJ markedly inhibited tumor growth, relieved the pathological lesions, lowered the expression of Ki67, and regulated the expression of the apoptosis-associated protein. Moreover, we observed that RSJ can inhibit the Jak2/Stat3 signaling pathway both in vivo and in vitro. Overall, our research reveals that RSJ can alleviate BC by triggering the mitochondrial apoptosis pathway and suppressing the Jak2/Stat3 pathway, providing new dietary intervention strategies for BC.
- Subjects
FRUIT; IN vitro studies; CYTOLOGY; MITOCHONDRIA; RESEARCH funding; BREAST tumors; ANTINEOPLASTIC agents; APOPTOSIS; CELL proliferation; CELLULAR signal transduction; IN vivo studies; PLANT extracts; JANUS kinases; MICE; CELL lines; GENE expression; ANIMAL experimentation; ONCOGENES; STAT proteins; PHARMACODYNAMICS
- Publication
Nutrients, 2024, Vol 16, Issue 16, p2784
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16162784