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- Title
High Plasma Lactate Levels Are Associated With Increased Risk of In-hospital Mortality in Patients With Pulmonary Embolism.
- Authors
Vanni, Simone; Socci, Filippo; Pepe, Giuseppe; Nazerian, Peiman; Viviani, Gabriele; Baioni, Michele; Conti, Alberto; Grifoni, Stefano
- Abstract
ACADEMIC EMERGENCY MEDICINE 2011; 18:830-835 © 2011 by the Society for Academic Emergency Medicine Abstract Objectives: The objective was to investigate the prognostic value of plasma lactate in patients with acute pulmonary embolism (PE). Methods: This was a retrospective study at the emergency department (ED) of a third-level teaching hospital. The authors considered consecutive patients with a diagnosis of PE established by lung scan or spiral computed tomography (CT) and confirmed by pulmonary angiography if necessary. Only patients for whom plasma lactate levels had been tested within 6 hours from presentation to the ED were included. Primary outcome was in-hospital death due to any cause; secondary outcome was mortality related to PE. Results: From September 1997 to June 2006, a total of 384 patients were diagnosed with PE in the ED. Of these patients, 287 had registered plasma lactate levels and were included in this analysis. Included patients had a mean age of 70 (SD ± 15 years, range = 18 to 100 years), 163 (57%) were female, 26 (9%) showed systolic blood pressure lower than 100 mm Hg at presentation, and 160 (56%) had echocardiographic evidence of right ventricular dysfunction (RVD). Twenty patients died during their hospital stay (7%). Plasma lactate levels ≥ 2 mmol/L were associated with in-hospital mortality from all causes (odds ratio [OR] = 4.60, 95% confidence interval [CI] = 1.57 to 13.53) and with PE-related mortality (OR = 4.94, 95% CI = 1.38 to 17.63), independent of hypotension or RVD at presentation. Conclusions: High plasma lactate was associated with increased in-hospital mortality in this sample of patients with acute PE.
- Subjects
MORTALITY risk factors; MEDICAL needs assessment; TOMOGRAPHY; ANALYSIS of variance; CONFIDENCE intervals; REPORTING of diseases; ECHOCARDIOGRAPHY; EMERGENCY medicine; FISHER exact test; HOSPITAL patients; LACTATES; MEDICAL societies; MUSCLE proteins; PANEL analysis; DATA analysis; PULMONARY embolism; RETROSPECTIVE studies; RECEIVER operating characteristic curves; DATA analysis software; DIAGNOSIS
- Publication
Academic Emergency Medicine, 2011, Vol 18, Issue 8, p830
- ISSN
1069-6563
- Publication type
Article
- DOI
10.1111/j.1553-2712.2011.01128.x