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- Title
Oral isotretinoin for treating mucocutaneous human papillomavirus infections: A systematic review and meta-analysis.
- Authors
Yang, Ting-Hua; Lee, Tsai-Hsien; Huang, Yu-Chen
- Abstract
<bold>Introduction: </bold>Some viral warts are refractory to treatment, some others tend to recur. Oral isotretinoin is useful against warts to varying degrees.<bold>Objective: </bold>To determine the efficacy of oral isotretinoin for treating mucocutaneous human papillomavirus infections.<bold>Methods: </bold>A systematic review and meta-analysis of studies published from the date of inception of the databases to December 30, 2017 were conducted. Randomized controlled trials or case series with ≥10 patients with mucocutaneous human papillomavirus infection who had received oral isotretinoin treatment were analyzed. The meta-analysis estimated the pooled odds ratio and pooled response rate.<bold>Results: </bold>The review included eight studies. Trials of oral isotretinoin versus placebo treatment revealed that isotretinoin effectively treated mucocutaneous human papillomavirus infections (odds ratio: 43.8, 95% confidence interval: 9.7-198.8). The pooled estimate of the complete response rate of oral isotretinoin to mucocutaneous human papillomavirus was 67.7% (95% confidence interval: 49.5-81.7%). Another pooled estimation revealed that 83.9% (95% confidence interval: 59.7-94.9%) of patients exhibited at least 50% lesion clearance, whereas 12.3% with complete response experienced recurrence.<bold>Limitations: </bold>This meta-analysis had a small sample size and high inter-study heterogeneity.<bold>Conclusion: </bold>Oral isotretinoin is superior to placebo for treating mucocutaneous human papillomavirus infections, particularly plane warts. The recurrence rate and risk of severe side effects are low.
- Subjects
PAPILLOMAVIRUS diseases; WARTS; META-analysis; ISOTRETINOIN; RANDOMIZED controlled trials; DRUG side effects; PAPILLOMAVIRUS disease diagnosis; CLINICAL trials; COMPARATIVE studies; DERMATOLOGIC agents; RESEARCH methodology; MEDICAL cooperation; MUCOUS membranes; ORAL drug administration; PAPILLOMAVIRUSES; RESEARCH; SKIN; EVALUATION research
- Publication
Indian Journal of Dermatology, Venereology & Leprology, 2019, Vol 85, Issue 6, p569
- ISSN
0378-6323
- Publication type
journal article
- DOI
10.4103/ijdvl.IJDVL_269_18