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- Title
Different Long-Term Outcomes of Abdominal Aortic Aneurysm and Intracranial Aneurysm Models: Hemodynamic Change may also Play an Essential Role in the Initiation and Progression of Abdominal Aortic Aneurysm in Rabbits.
- Authors
Bi, Yonghua; Han, Xinwei; Zhong, Hongshan; Xu, Ke; Qi, Xun; Zhang, Zhen; Li, Weixiao
- Abstract
Self-healing phenomenon was found in the periarterial elastase-induced abdominal aortic aneurysm (AAA) in rabbit. This kind of aneurysm model does not progress and heals spontaneously in the long term, which is quite different from the performance of AAA disease in human. In order to better mimic human AAA and overcome this shortcoming of traditional AAA model in rabbit, we studied the pathogenesis of cerebral aneurysm (CA) model in small animal, which shows an excellent long-term patency and progressive enlargement. We found that hemodynamic conditions, such as turbulence flow, high blood flow, and shear stress, play an important role in the formation and progression of CA. So, we hypothesize that hemodynamic change may also play an essential role in the initiation and progression of rabbit AAA, and self-healing will be overcome if hemodynamic condition changes by coarctation of infra-renal aorta after elastase incubation.
- Subjects
HEMODYNAMICS; AORTIC aneurysm treatment; INTRACRANIAL aneurysms; LABORATORY rabbits; BIOLOGICAL fluid dynamics; THERAPEUTICS
- Publication
Cell Biochemistry & Biophysics, 2014, Vol 70, Issue 2, p819
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-014-9985-5