We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of two questionnaires to assess gastrointestinal toxicity in dogs and cats treated with chemotherapy.
- Authors
Malone, E. K.; Rassnick, K. M.; Bailey, D. B.; Kiselow, M. A.; Erb, H. N.
- Abstract
Questionnaires completed by pet owners are widely used instruments to monitor adverse gastrointestinal (GI) effects in the owners' animals undergoing chemotherapy and for reporting toxicoses in clinical trials; however, no questionnaires have been formally evaluated. This study compares two questionnaire-based evaluations of adverse GI events: a basic, open-ended questionnaire and a detailed questionnaire modelled after the grading in the Veterinary Co-operative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE). Owners completed both questionnaires after their dog or cat received moderately emetogenic chemotherapy. Results were used to derive toxicity grades for anorexia, vomiting and diarrhoea. We evaluated 123 pairs of questionnaires. Disagreement in grade of anorexia, vomiting and diarrhoea was found in 24, 7 and 13% of paired questionnaires, respectively ( κ = 0.63, 0.83 and 0.71, respectively). Although 'good' to 'very good' agreement was found, the potential for only 'fair' agreement between questionnaire methods is of concern and suggests a need to adopt a standardized form.
- Subjects
QUESTIONNAIRES; DRUG therapy; INTESTINAL diseases; CLINICAL trials; MEDICAL research; NAUSEA
- Publication
Veterinary & Comparative Oncology, 2011, Vol 9, Issue 3, p225
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5829.2010.00259.x