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- Title
Reactive Amphiphilic Conjugated Polymers for Inhibiting Amyloid β Assembly.
- Authors
Sun, Han; Liu, Jing; Li, Shengliang; Zhou, Lingyun; Wang, Jianwu; Liu, Libing; Lv, Fengting; Gu, Qi; Hu, Baoyang; Ma, Yuguo; Wang, Shu
- Abstract
Protein misfolding and aberrant aggregations are associated with multiple prevalent and intractable diseases. Inhibition of amyloid assembly is a promising strategy for the treatment of amyloidosis. Reported here is the design and synthesis of a reactive conjugated polymer, a poly(p‐phenylene vinylene) derivative, functionalized with p‐nitrophenyl esters (PPV‐NP) and it inhibits the assembly of amyloid proteins, degrades preformed fibrils, and reduces the cytotoxicity of amyloid aggregations in living cells. PPV‐NP is attached to the proteins through hydrophobic interactions and irreversible covalent linkage. PPV‐NP also exhibited the capacity to eliminate Aβ plaques in brain slices in ex vivo assays. This work represents an innovative attempt to inhibit protein pathogenic aggregates, and may offer insights into the development of therapeutic strategies for amyloidosis.
- Subjects
AMPHIPHILES; CONJUGATED polymers; AMYLOID; NITROPHENYL compounds; CLUSTERING of particles
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 18, p6049
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201901459