We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Palladium‐Catalyzed Divergent Cyclopropanation by Regioselective Solvent‐Driven C(sp<sup>3</sup>)−H Bond Activation.
- Authors
Chung, Da Sol; Lee, Jae Sung; Ryu, Ho; Park, Jiyong; Kim, Hyunjoong; Lee, Joo Hyun; Kim, U Bin; Lee, Won Koo; Baik, Mu‐Hyun; Lee, Sang‐gi
- Abstract
Reported is a tandem palladium‐catalyzed Heck/regioselective C(sp3)−H activation reaction for the divergent synthesis of spiro‐ and fused‐cyclopropanated indolines from N‐methallylated 2‐bromoarylamides. The regioselectivity of the C−H bond activation in the σ‐alkylPdII intermediate is controlled by the solvent used. DFT calculations suggest that the polarity of solvent molecules could influence the transition‐state energy, leading to a bifurcation of the C−H bond activation in the σ‐alkylPdII intermediate.
- Subjects
PALLADIUM; CYCLOPROPANATION; REGIOSELECTIVITY (Chemistry); INDOLINE; MOLECULES
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 47, p15686
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201809133