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- Title
Enantioselective Dearomative Difunctionalization of Indoles by Palladium-Catalyzed Heck/Sonogashira Sequence.
- Authors
Liu, Ren ‐ Rong; Wang, Yong ‐ Gang; Li, Ying ‐ Long; Huang, Bing ‐ Bing; Liang, Ren ‐ Xiao; Jia, Yi ‐ Xia
- Abstract
Palladium-catalyzed enantioselective dearomative arylalkynylation of N-substituted indoles, through a Heck/Sonogashira sequence, was established using a new BINOL-based phosphoramidite as the chiral ligand. A wide range of 2,3-disubstituted indolines, bearing vicinal quaternary and tertiary stereocenters, were efficiently constructed in one step with excellent enantioselectivities (up to 97 % ee) and diastereoselectivities (>20:1).
- Subjects
INDOLE compounds; PALLADIUM catalysts; SONOGASHIRA reaction; PHOSPHORAMIDITES; CHIRALITY
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 26, p7583
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201703833