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- Title
Ligand-Promoted Rhodium(III)-Catalyzed ortho-C−H Amination with Free Amines.
- Authors
Wang, Huai ‐ Wei; Lu, Yi; Zhang, Bing; He, Jian; Xu, Hua ‐ Jin; Kang, Yan ‐ Shang; Sun, Wei ‐ Yin; Yu, Jin ‐ Quan
- Abstract
Ligand development for rhodium(III)-catalyzed C−H activation reactions has largely been limited to cyclopentadienyl (Cp) based scaffolds. 2-Methylquinoline has now been identified as a feasible ligand that can coordinate to the metal center of Cp*RhCl to accelerate the cleavage of the C−H bond of N-pentafluorophenylbenzamides, providing a new structural lead for ligand design. The compatibility of this reaction with secondary free amines and anilines also overcomes the limitations of palladium(II)-catalyzed C−H amination reactions.
- Subjects
RHODIUM catalysts; AMINATION; CARBON-hydrogen bonds; AMINES; LIGANDS (Chemistry); QUINOLINE
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 26, p7557
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201703300