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- Title
Physico-chemical and pro-wound healing properties of microporous cellulosic sponge from Gleditsia triacanthos pods functionalized with Phytolacca americana fruit extract.
- Authors
Marinas, Ioana Cristina; Gradisteanu Pircalabioru, Gratiela; Oprea, Eliza; Geana, Elisabeta-Irina; Zgura, Irina; Romanitan, Cosmin; Matei, Elena; Angheloiu, Marian; Brincoveanu, Oana; Georgescu, Mihaela; Chifiriuc, Mariana Carmen
- Abstract
This study aimed to exploit two invasive plant species to develop a novel, multifunctional, bioactive wound dressing based on a microporous cellulosic sponge (CS) from Gleditsia triacanthos pods and functionalizing them with Phytolacca americana fruit extract. The CS was functionalized, lyophilized, and characterized by Attenuated total reflectance–Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, contact angle, water absorption, and retention capacity. In addition, two parameters were evaluated in temporal dynamics: controlled release of phenolic compounds and antioxidant activities. The hemolytic index, blood clotting kinetics, lactate dehydrogenase release, and wound scratch assays proved their hemo- and biocompatibility, as well as their ability to promote cell proliferation and migration promoting-activity and to inhibit microbial growth. Furthermore, the obtained spongious material exhibited an anti-inflammatory effect by modulating the macrophages' secretion profile of IL-6 and IL-10. In conclusion, the microporous cellulosic sponge obtained from G. triacanthos could be used as a vehicle to ensure the controlled release of bioactive principles with pro-wound healing activities extracted from invasive plants.
- Subjects
FRUIT extracts; HEALING; BLOOD coagulation; CELL migration; INVASIVE plants
- Publication
Cellulose, 2023, Vol 30, Issue 16, p10313
- ISSN
0969-0239
- Publication type
Article
- DOI
10.1007/s10570-023-05491-3