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- Title
Is there any interplay between human gut microbiota and upper airway susceptibility to recurrent respiratory papillomatosis exacerbations?
- Authors
Klimza, Hanna; Jackowska, Joanna; Zagozda, Natalia; Wierzbicka, Małgorzata
- Abstract
Introduction: Recurrent respiratory papillomatosis is a long-term disease caused by HPV 6 and 11, but there is still no consensus on the factors that may influence its course. Aim: The aim of the study is the analysis of the recurrent activity of respiratory papillomatosis measured by the number of surgeries and recent disease activity, as well as an interview regarding intestinal symptoms. Material and methods: Our study involved 73 patients with confirmed papillomatosis (39 men, 34 women). The main variables of crucial importance for the severity of papilloma disease were: age of onset, number of operations, and current disease activity. Variables important for the analysis of the impact of intestinal dysbiosis on the course of papillomatosis were as follows: intestinal symptoms and the number of antibiotic courses in the last year. The main outcome measure in this study was the relationship between papilloma activity and indicators of intestinal microflora status. Results: Our results showed that diet had a statistically significant effect on the last disease activity measured by the interval recurrence of RRP (P = 0.005). The remaining variables did not affect the number of surgeries performed during the patient's lifetime or the current RRP status. Conclusions: The acquired knowledge may contribute to further work on the discovery of the relationship between the state of the intestinal microbiota and the course of recurrence of respiratory papillomatosis infection in patients with recurrent respiratory papillomatosis.
- Subjects
PAPILLOMAVIRUS diseases; HUMAN microbiota; GUT microbiome; FECAL microbiota transplantation; AGE of onset; NONINVASIVE ventilation; DISEASE exacerbation
- Publication
Polish Otolaryngology / Otolaryngologia Polska, 2024, Vol 78, Issue 3, p1
- ISSN
0030-6657
- Publication type
Article
- DOI
10.5604/01.3001.0054.4733