We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tailored Viral-like Particles as Drivers of Medical Breakthroughs.
- Authors
Travassos, Rafael; Martins, Sofia A.; Fernandes, Ana; Correia, João D. G.; Melo, Rita
- Abstract
Despite the recognized potential of nanoparticles, only a few formulations have progressed to clinical trials, and an even smaller number have been approved by the regulatory authorities and marketed. Virus-like particles (VLPs) have emerged as promising alternatives to conventional nanoparticles due to their safety, biocompatibility, immunogenicity, structural stability, scalability, and versatility. Furthermore, VLPs can be surface-functionalized with small molecules to improve circulation half-life and target specificity. Through the functionalization and coating of VLPs, it is possible to optimize the response properties to a given stimulus, such as heat, pH, an alternating magnetic field, or even enzymes. Surface functionalization can also modulate other properties, such as biocompatibility, stability, and specificity, deeming VLPs as potential vaccine candidates or delivery systems. This review aims to address the different types of surface functionalization of VLPs, highlighting the more recent cutting-edge technologies that have been explored for the design of tailored VLPs, their importance, and their consequent applicability in the medical field.
- Subjects
VIRUS-like particles; STRUCTURAL stability; SMALL molecules; MAGNETIC fields; IMMUNE response; MAGNETIC nanoparticle hyperthermia
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 12, p6699
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25126699