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- Title
Association of health-related quality of life with gender in patients with B-cell chronic lymphocytic leukemia.
- Authors
Pashos, Chris; Flowers, Christopher; Kay, Neil; Weiss, Mark; Lamanna, Nicole; Farber, Charles; Lerner, Susan; Sharman, Jeff; Grinblatt, David; Flinn, Ian; Kozloff, Mark; Swern, Arlene; Street, Thomas; Sullivan, Kristen; Harding, Gale; Khan, Zeba
- Abstract
Purpose: This analysis examined associations between gender and health-related quality of life (HRQOL) in patients with B-cell chronic lymphocytic leukemia (CLL) as they initiate therapy for CLL outside the clinical trial setting. Methods: Baseline data were collected as part of Connect® CLL Registry, a prospective observational study initiated in community, academic, and government centers. Patient demographics and clinical characteristics were provided by clinicians. Patients reported HRQOL using the Brief Fatigue Inventory (BFI), EQ-5D, and Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu). Mean scores were analyzed, with statistical significance of differences determined by ANOVA. Multivariate analysis also considered age and line of therapy. Results: Baseline HRQOL data were available for 1,140 patients: 710 (62 %) men and 430 (38 %) women from 161 centers. Patients were predominantly white (89 %) with mean age 69 ± 11 years. Women reported significantly worse global fatigue ( P <0.0001), fatigue severity ( P <0.0001), and fatigue-related interference ( P = 0.0005) versus men (BFI). Pain/discomfort ( P = 0.0077), usual activities ( P = 0.0015), and anxiety/depression ( P = 0.0117) were significantly worse in women than in men (EQ-5D). With women reporting a better social/family score ( P = 0.0238) and men reporting a better physical score ( P = 0.0002), the mean FACT-G total score did not differ by gender. However, the mean FACT-Leu total score was better among men versus women ( P = 0.0223), primarily because the mean leukemia subscale score was significantly better among men ( P <0.0001). Multivariate analysis qualitatively confirmed these findings. Conclusions: Connect® CLL Registry results indicate that significant differences exist in certain HRQOL domains, as women reported greater levels of fatigue and worse functioning in physical domains.
- Subjects
QUALITY of life; CHRONIC lymphocytic leukemia; SCIENTIFIC observation; DEMOGRAPHIC surveys; FATIGUE (Physiology); ANXIETY; MENTAL depression
- Publication
Supportive Care in Cancer, 2013, Vol 21, Issue 10, p2853
- ISSN
0941-4355
- Publication type
Article
- DOI
10.1007/s00520-013-1854-z