We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of pain response and functional interference outcomes between spinal and non-spinal bone metastases treated with palliative radiotherapy.
- Authors
Zeng, Liang; Chow, Edward; Zhang, Liying; Culleton, Shaelyn; Holden, Lori; Jon, Florencia; Khan, Luluel; Tsao, May; Barnes, Elizabeth; Danjoux, Cyril; Sahgal, Arjun
- Abstract
Purpose: The purpose of this study was to compare functional interference and pain response outcomes using the Brief Pain Inventory (BPI) for patients treated with palliative radiotherapy to spine versus non-spine bones and determine if dose fractionation was associated with each group's respective response. Materials and methods: Patients treated for painful bone metastases with palliative radiotherapy during May 2003 to June 2007 were analyzed. The BPI was utilized at baseline and monthly for 6 months post-radiation. Pain response was determined using International Bone Metastases Consensus response definitions. Wilcoxon rank-sum test (for continuous variable), Fisher exact test (for categorical value), and two-way analysis of variance were used for comparisons, and a p value of ≤0.05 was considered statistically significant. Results: Three hundred eighty-six patients were analyzed, 62% were treated with a single fraction, 38% with multiple fractions. Pain and functional interference scores significantly improved over time in both spine and non-spine sites. At 3 months, 42% of all patients had a partial response, and 25% had a complete response. Location of bone metastases and radiotherapy dose were not predictive factors for pain response nor functional interference following radiation treatment. Conclusion: Spine and non-spine bone metastases exhibited similar pain and functional interference improvements over a period of 6 months post-radiotherapy. There were, however, high attrition rates as expected with palliative studies, with approximately half the patients remaining in this study by 3 months and a fifth by 6 months. A single 8 Gy resulted in equal benefits in terms of both pain response and improvement in function.
- Subjects
BONE metastasis; SPINE cancer; CANCER radiotherapy; PALLIATIVE treatment of cancer; CANCER pain
- Publication
Supportive Care in Cancer, 2012, Vol 20, Issue 3, p633
- ISSN
0941-4355
- Publication type
Article
- DOI
10.1007/s00520-011-1144-6