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- Title
Pancreatic surgery for tumors in children and adolescents.
- Authors
Sacco Casamassima, Maria; Gause, Colin; Goldstein, Seth; Abdullah, Fizan; Meoded, Avner; Lukish, Jeffrey; Wolfgang, Christopher; Cameron, John; Hackam, David; Hruban, Ralph; Colombani, Paul; Sacco Casamassima, Maria G; Gause, Colin D; Goldstein, Seth D; Lukish, Jeffrey R; Wolfgang, Christopher L; Hackam, David J; Hruban, Ralph H; Colombani, Paul M
- Abstract
<bold>Purpose: </bold>Pancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies.<bold>Methods: </bold>We conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent surgery at a single institution between 1995 and 2015.<bold>Results: </bold>Nineteen patients were identified with a median age at operation of 16.6 years (IQR 13.5-18.9). The most common histology was solid pseudopapillary neoplasm (SPN) (n = 13), followed by pancreatic neuroendocrine tumor (n = 3), serous cystadenoma (n = 2) and pancreatoblastoma (n = 1). Operative procedures included formal pancreatectomy (n = 17), enucleation (n = 1) and central pancreatectomy (n = 1). SPNs were noninvasive in all but one case with perineural, vascular and lymph node involvement. Seventeen patients (89.5 %) are currently alive and disease free at a median follow-up of 5.7 (IQR 3.7-10.9) years. Two patients died: one with metastatic insulinoma and another with SPN who developed peritoneal carcinomatosis secondary to a concurrent rectal adenocarcinoma.<bold>Conclusions: </bold>Pediatric pancreatic tumors are a heterogeneous group of neoplastic lesions for which surgery can be curative. SPN is the most common histology, is characterized by low malignant potential and in selected cases can be safely and effectively treated with a tissue-sparing resection and minimally invasive approach.
- Subjects
PANCREATIC tumors; PANCREATIC surgery; TUMORS in children; TUMORS in adolescence; CARCINOMA; TUMOR treatment; TUMOR diagnosis; TUMOR surgery; COMBINED modality therapy; NEUROENDOCRINE tumors; PANCREATECTOMY; TUMORS; RETROSPECTIVE studies; DIAGNOSIS
- Publication
Pediatric Surgery International, 2016, Vol 32, Issue 8, p779
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-016-3925-y