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- Title
Isolation of Hafnia paralvei co-harbouring bla<sub>NDM-1</sub> and bla<sub>VIM-1</sub> in a woman who underwent allogeneic hematopoietic stem cell transplantation.
- Authors
Appel, Tobias Manuel; Stein, Claudia; Brandt, Christian; Rödel, Jürgen; Frietsch, Jochen J.; Miethke, Jenny; Hochhaus, Andreas; Hilgendorf, Inken
- Abstract
Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility testing yielded resistance to trimethoprim/sulfamethoxazole, colistin, fosfomycin and all β-lactams, except cefiderocol. Whole genome sequencing revealed the presence of plasmid-encoded NDM-1 and VIM-1 carbapenemases. This finding highlights the importance of epidemiological surveillance and new therapeutic options for MBL.
- Subjects
ANTIMICROBIAL stewardship; COLISTIN; SEQUENCE analysis; ULTRASONIC imaging; CARBAPENEM-resistant bacteria; ENTEROBACTERIACEAE; BETA lactamases; HEMATOPOIETIC stem cell transplantation; DRUG resistance in microorganisms; MICROBIAL sensitivity tests
- Publication
Infection, 2023, Vol 51, Issue 4, p1161
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-022-01976-8