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- Title
GAS6 Oncogene and Reverse MLLT3-KMT2A Duplications in an Infant with Acute Myeloid Leukemia and a Novel Complex Hyperdiploid Karyotype: Detailed High-Resolution Molecular Cytogenetic Studies.
- Authors
Capela de Matos, Roberto R.; Ney Garcia, Daniela R.; Cifoni, Elaine; Othman, Moneeb a.K.; Tavares de Souza, Mariana; Carboni, Edna K.; Ferreira, Gerson M.; Liehr, Thomas; Ribeiro, Raul C.; M. Silva, Maria Luiza
- Abstract
Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease, presenting cytogenetic and molecular abnormalities which turned out to be critical prognostic factors. Ploidy changes as gain or loss of individual chromosomes are rare in AML, occurring only in about 1-2% of the affected children. Hyperdiploid karyotypes are exceedingly rare in infants less than 12 months of age. In this age group, structural rearrangements involving the KMT2A gene occur in about 58% of the cases. Among them, the translocation t(9; 11)(p22;q23), KMT2A-MLLT3, is the most common ab-normality accounting for approximately 22% of KMT2A rearrangements in infant AML cases. Here, we describe a 7-month-old girl with a history of fever and severe diarrhea, and a physical examination remarkable for pallor and hepatosplenomegaly. A novel complex hyperdiploid karyotype 53,XX,+X,+6,t(9; 11)(p21.3;q23.3),+der(9)t(9; 11) (p21.3;q23.3),dup(13)(q31q34),+14,+19,+21,+22 was characterized by high-resolution molecular cytogenetic approaches. Fluorescence in situ hybridization, multiplex-FISH, and multicolor chromosome banding were applied, revealing 2 reverse MLLT3-KMT2A fusions and a duplication of the GAS6 oncogene. Our work suggests that molecular cytogenetic studies are crucial for the planning of a proper strategy for risk therapy in AML infants with hyperdiploid karyotypes.
- Subjects
MYELOID leukemia; NONLYMPHOID leukemia; KARYOTYPES; PRELEUKEMIA; MYELODYSPLASTIC syndromes
- Publication
Cytogenetic & Genome Research, 2017, Vol 152, Issue 1, p33
- ISSN
1424-8581
- Publication type
Article
- DOI
10.1159/000477108