We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CT Perfusion evaluation of gastric cancer: correlation with histologic type.
- Authors
Lee, Dong Ho; Kim, Se Hyung; Joo, Ijin; Han, Joon Koo
- Abstract
<bold>Objectives: </bold>To prospectively evaluate if the perfusion parameters of gastric cancer can provide information on histologic subtypes of gastric cancer.<bold>Methods: </bold>We performed preoperative perfusion CT (PCT) and curative gastrectomy in 46 patients. PCT data were analysed using a dedicated software program. Perfusion parameters were obtained by two independent radiologists and were compared according to histologic type using Kruskal-Wallis, Mann-Whitney U test and receiver operating characteristic analysis. To assess inter-reader agreement, we used intraclass correlation coefficient (ICC).<bold>Results: </bold>Inter-reader agreement for perfusion parameters was moderate to substantial (ICC = 0.585-0.678). Permeability surface value of poorly cohesive carcinoma (PCC) was significantly higher than other histologic types (47.3 ml/100 g/min in PCC vs 26.5 ml/100 g/min in non-PCC, P < 0.001). Mean transit time (MTT) of PCC was also significantly longer than non-PCC (13.0 s in PCC vs 10.3 s in non-PCC, P = 0.032). The area under the curve to predict PCC was 0.891 (P < 0.001) for permeability surface and 0.697 (P = 0.015) for MTT.<bold>Conclusion: </bold>Obtaining perfusion parameters from PCT was feasible in gastric cancer patients and can aid in the preoperative imaging diagnosis of PCC-type gastric cancer as the permeability surface and MTT value of PCC type gastric cancer were significantly higher than those of non-PCC.<bold>Key Points: </bold>• Obtaining perfusion parameters from PCT was feasible in patients with gastric cancer. • Permeability surface and MTT were significantly higher in poorly cohesive carcinoma (PCC). • Permeability surface, MTT can aid in the preoperative imaging diagnosis of PCC.
- Subjects
GASTRECTOMY; PERFUSION; BODY fluids; COMPUTED tomography; ONCOLOGY; HISTOLOGY; STOMACH tumors; DIFFERENTIAL diagnosis; TUMOR classification; RECEIVER operating characteristic curves; DIAGNOSIS
- Publication
European Radiology, 2018, Vol 28, Issue 2, p487
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-4979-5