We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Software performance in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas.
- Authors
Cohen, Julien; Goo, Jin; Park, Chang; Kim, Young; Yoo, Roh-Eul; Lee, Chang; Ginneken, Bram; Chung, Doo; Cohen, Julien G; Goo, Jin Mo; Park, Chang Min; Lee, Chang Hyun; van Ginneken, Bram; Chung, Doo Hyun; Kim, Young Tae
- Abstract
<bold>Objective: </bold>To evaluate the performance of software in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas.<bold>Method: </bold>Seventy-three pulmonary adenocarcinomas manifesting as subsolid nodules were included. Two radiologists measured the maximal axial diameter of the ground-glass components on lung windows and that of the solid components on lung and mediastinal windows. Nodules were segmented using software by applying five (-850 HU to -650 HU) and nine (-130 HU to -500 HU) attenuation thresholds. We compared the manual and software measurements of ground-glass and solid components with pathology measurements of tumour and invasive components.<bold>Results: </bold>Segmentation of ground-glass components at a threshold of -750 HU yielded mean differences of +0.06 mm (p = 0.83, 95 % limits of agreement, 4.51 to 4.67) and -2.32 mm (p < 0.001, -8.27 to 3.63) when compared with pathology and manual measurements, respectively. For solid components, mean differences between the software (at -350 HU) and pathology measurements and between the manual (lung and mediastinal windows) and pathology measurements were -0.12 mm (p = 0.74, -5.73 to 5.55]), 0.15 mm (p = 0.73, -6.92 to 7.22), and -1.14 mm (p < 0.001, -7.93 to 5.64), respectively.<bold>Conclusion: </bold>Software segmentation of ground-glass and solid components in subsolid nodules showed no significant difference with pathology.<bold>Key Points: </bold>• Software can effectively segment ground-glass and solid components in subsolid nodules. • Software measurements show no significant difference with pathology measurements. • Manual measurements are more accurate on lung windows than on mediastinal windows.
- Subjects
PULMONARY adenomatosis; ADENOCARCINOMA; SOFTWARE measurement; RADIOLOGISTS; GLASS
- Publication
European Radiology, 2016, Vol 26, Issue 12, p4465
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4317-3