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- Title
Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer.
- Authors
Goh V; Shastry M; Engledow A; Reston J; Wellsted DM; Peck J; Endozo R; Rodriguez-Justo M; Taylor SA; Halligan S; Groves AM; Goh, Vicky; Shastry, Manu; Engledow, Alec; Reston, Jonathan; Wellsted, David M; Peck, Jacqui; Endozo, Raymondo; Rodriguez-Justo, Manuel; Taylor, Stuart A
- Abstract
<bold>Objective: </bold>To determine how commercial software platform upgrades impact on derived parameters for colorectal cancer.<bold>Materials and Methods: </bold>Following ethical approval, 30 patients with suspected colorectal cancer underwent Perfusion CT using integrated 64 detector PET/CT before surgery. Analysis was performed using software based on modified distributed parameter analysis (Perfusion software version 4; Perfusion 4.0), then repeated using the previous version (Perfusion software version 3; Perfusion 3.0). Tumour blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were determined for identical regions-of-interest. Slice-by-slice and 'whole tumour' variance was assessed by Bland-Altman analysis.<bold>Results: </bold>Mean BF, BV and PS was 20.4%, 59.5%, and 106% higher, and MTT 14.3% shorter for Perfusion 4.0 than Perfusion 3.0. The mean difference (95% limits of agreement) were +13.5 (-44.9 to 72.0), +2.61 (-0.06 to 5.28), -1.23 (-6.83 to 4.36), and +14.2 (-4.43 to 32.8) for BF, BV, MTT and PS respectively. Within subject coefficient of variation was 36.6%, 38.0%, 27.4% and 60.6% for BF, BV, MTT and PS respectively indicating moderate to poor agreement.<bold>Conclusion: </bold>Software version upgrades of the same software platform may result in significantly different parameter values, requiring adjustments for cross-version comparison.
- Publication
European Radiology, 2011, Vol 21, Issue 4, p744
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1967-4