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- Title
Anti-Inflammatory Mechanism of Prozime-10, a Proteolytic Enzyme.
- Authors
Maki, Kazuo; Takahashi, Hitomi; Kakimoto, Masanori; Nakajima, Masatoshi; Tasaka, Kenji
- Abstract
When Prozime-10 (P-10), a protease extracted from cultured broth of Aspergillus melleus, was injected intravenously into anesthetized dogs, plasma ACTH was increased with a latency of 30 min, and this was followed by remarkable elevation of plasma cortisol in many instances. A similar increase in plasma cortisol was elicited after trypsin and α-chymotrypsin were injected. Plasma histamine was raised promptly prior to an increase in plasma ACTH after P-10 in every case. However, in certain cases, changes in cortisol occurred simultaneously with ACTH after P-10. Such a rapid elevation of cortisol can be explained, partly, by direct stimulation of the adrenal cortex by histamine. Copyright © 1981 S. Karger AG, Basel
- Publication
Pharmacology, 1981, Vol 23, Issue 4, p230
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000137554