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- Title
Comparative Efficacy of Ceftriaxone in Experimental Infections Involving Bacteroides fragilis and Escherichia coii.
- Authors
Dezfulian, Manoucher; Bitar, Roger A.; Bartlett, John G.
- Abstract
The in vivo activity of ceftriaxone was examined in an experimentally induced subcutaneous infection involving Bacteroides fragilis and Escherichia coli. Mice were challenged with 1 of 10 strains of B. fragilis or E. coli, or a dual combination of the two species. The efficacy was measured by a reduction in the count of viable organisms when antimicrobial treatment was initiated 1 h after challenge and continued for 5 days. Ceftriaxone exhibited impressive activity against E. coli but showed poor in vivo activity versus B. fragilis. The antimicrobial activity of ceftriaxone was influenced by the microbial interaction in our dual-isolate model. Pharmacokinetic studies showed that ceftriaxone penetrated into abscesses and achieved peak levels of about 40% of the peak serum levels. However, in abscesses infected with B. fragilis nearly all biological activity of ceftriaxone was lost. Copyright © 1993 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1993, Vol 39, Issue 5, p355
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000239147