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- Title
Effect of Different Dietary Fats on the Fæcal End-Products of Cholesterol Metabolism.
- Authors
GORDON, H.; LEWIS, B.; EALES, L.; BROCK, J. F.
- Abstract
INVESTIGATORS in several laboratories, including our own1, have shown that certain unsaturated fats are able to lower the serum cholesterol-level of human subjects. It is possible that this effect is achieved by an increase in the excretion of the end-products of cholesterol metabolism; hence we have commenced a study of the quantitative changes in these end-products during the administration of different dietary fats. Following the demonstration that ingested cholesterol 4-14C is excreted mainly as cholic acid both in rats2 and in a human bile fistula patient3, particular attention was paid to the bile-acid content of the fæces (estimated by the method of Lewis4). In addition, the Liebermann-Burchard reacting neutral sterols of the fæces were measured by the method of Abell et al.5 and total fæcal lipid according to van de Kamer et al.6. The serum cholesterol was also measured by the method of Abell et al.5.
- Publication
Nature, 1957, Vol 180, Issue 4592, p923
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/180923b0