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- Title
Synthesis of new derivatives of pyrido[1,2- a]triazine.
- Authors
Dotsenko, V.; Krivokolysko, S.; Litvinov, V.
- Abstract
The article discusses the synthesis of pyrido[1,2-a]triazine derivatives from 6-amino-4-(het)aryl-2-thioxopyridine-3,5-dicarbonitriles. 6-amino-4-(het)aryl-2-thioxopyridine-3,5-dicarbonitriles are readily accessible by the reaction of arylmethylenemalonitriles with cyanothioacetamide under Mannich reaction conditions. 6-amino-4-(het)aryl-2-thioxopyridine-3,5-dicarbonitriles underwent aminomethylation with primary amines and HCHO to give pyrido[1,2-a]triazines.
- Subjects
TRIAZINES; ORGANIC synthesis; NITRILES; ORGANONITROGEN compounds; MANNICH reaction; METHYLATION
- Publication
Chemistry of Heterocyclic Compounds, 2007, Vol 43, Issue 4, p517
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-007-0080-3