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- Title
Comparative chemotherapeutic activity of new fluorinated 4-quinolones and standard agents against a variety of bacteria in a mouse infection model.
- Authors
Sesnie, Josephine C.; Fritsch, Peter W.; Griffin, Timothy J.; Heifetz, Carl L.; Leopold, Evangeline T.; Malta, Thomas E.; Shapiro, Martin A.; Vincent, Patrick; Sesnie, J C; Fritsch, P W; Griffin, T J; Heifetz, C L; Leopold, E T; Malta, T E; Shapiro, M A; Vincent, P W
- Abstract
The new fluorinated 4-quinolones appear to represent orally effective alternatives to parenteral and oral agents currently in use. A number of new fluorinated 4-quinolones were compared in acute systemic mouse-infection models with various Gram-positive cocci (streptococci and staphylococci), Enterobacteriaceae and Pseudomonas aeruginosa. Also included were standard oral and parenteral antimicrobial agents. CI-934 was the most potent quinolone in infections induced by Streptococcus pyogenes and Str. pneumoniae. CI-934, ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin were as effective as or superior to standard oral agents currently utilized in infections induced by the Enterobacteriaceae and staphylococci. They were active against antibiotic-susceptible strains and strains resistant to beta-lactams and gentamicin. Most were also quite potent against systemic P. aeruginosa mouse infections. These studies indicate good chemotherapeutic potential for the new generation fluorinated 4-quinolones in infections induced by the staphylococci, streptococci, Enterobacteriaceae and P. aeruginosa, including strains resistant to standard antimicrobial agents.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1989, Vol 23, Issue 5, p729
- ISSN
0305-7453
- Publication type
journal article