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- Title
Ampicillin resistance in Haemophilus influenzae--test methods for the activity of acylureidopenicillins, cephamycins and new cephalosporins.
- Authors
Newsom, S. W. B.; Matthews, Julie; Newsom, S W; Matthews, J
- Abstract
Tests for ampicillin susceptibility and -lactamases (confirmed by clavulanic acid inhibition) divided nine strains into three groups:- susceptible, resistant -lactamase producers, and resistant non -lactamase producers. Susceptibility of the strains to the acylureidopenicillins, cefotaxime, thienamycin, moxalactam, ceftazidime, cefoperazone, and cefotetan, was determined for stationary-phase inocula with high and low osmotic media to detect spheroplasts. The effect of inoculum size and metabolic state was tested on the resistant non -lactamase producers, which formed a definite group, comparatively resistant to most -lactamase stable antibiotics. Even low inocula were ampicillin-resistant. The -lactamase producers were relatively resistant to cefoperazone, and the acylureidopenicillins. Osmolarity affected ampicillin, cefuroxime, and thienamycin. Cefotetan and cefoxitin, although -lactamase stable, were relatively weak, while ceftazidime and cefotaxime were very active on all strains, and unaffected by osmolarity, inoculum size or metabolic state.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1982, Vol 10, Issue 6, p527
- ISSN
0305-7453
- Publication type
journal article